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The problem KLOW is designed to address is fragmentation
Mouse study reveals this may be connected to GLP-1s impact on the gut microbiome
Aydin Yildirim T, Kitis Y
Moreover, A double-blind study of patients with T2DM treated with metformin led to significant changes in the relative abundance of more than 80 bacterial species compared with placebo after 4 months, in which an increase in Escherichia and Akkermansia muciniphila and a decrease in Intestinibacter were also observed, whereas most of the changes with placebo occurred in phylum Firmicutes and phylum Proteobacteria (Wu et al., 2017)
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