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In addition, upregulation of GLUT1 altered the glucose metabolism pathway in [U-13C] labeled VSMCs, causing glucose to participate more in non-oxidative metabolism (such as glycolysis to produce lactate) and oxidative metabolism (such as entering the TCA cycle)
(2018) Protein levels of clusterin and glutathione synthetase in platelets allow for early detection of colorectal cancer, Cell
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Lactate promotes lactic acidification of histone H4 lysine 12 (H4K12la) by downregulating histone lysine delactase, inducing the enrichment of H4K12la in the SASP promoter region and SASP transcriptional activation to promote VSMC senescence
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