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Reduced kidney function and folate status are major confounders, since both can raise MMA and/or homocysteine independently of B12

Some protocols pulse AOD-9604 in five days on, two days off cycles, or run 12 week courses with breaks

Other researchers cited in the piece raised related concerns, including the absence of an identified receptor through which the peptide would be expected to act, a feature common to most peptide therapeutics