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Second, the role of metabolic reprogramming in ferroptosis highlights how sustained mechanical stress and inflammation reshape lipid, amino acid, iron, and glucose metabolic pathways in OA chondrocytes and synovial cells
Complement proteins C1q and C3 are increased in MS, and can be seen at synapses located within HLA-positive cell processes and in lysosomes, indicating opsonization and engulfment by microglia (150)
This might help treating physicians in making the right decisions on how to intervene and improve metabolism for the benefit of patients, and to understand why and how metabolism responds in their specific cases
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