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Most reported reactions overlap because both ultimately stimulate the same growth hormone release pathway
Puerarin protects retinal cells against apoptosis by antioxidant mechanisms such as lowering iNOS expression, increasing superoxide dismutase (SOD) activity, and preventing the production of advanced glycation end products (AGEs)
By inducing vascular dysfunction, inflammation, and oxidative stress, it becomes a key driver of aging in multiple organs such as the heart, brain, and kidneys
Human safety is not established because large human trials have not been completed
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