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Studies by Greenwood-Van Meerveld and colleagues using rodent POI models demonstrated that ipamorelin produced dose-dependent improvements in gastric emptying and reversal of POI-induced delayed gastrointestinal transit, with effects mediated through GHS-R1a expressed in gastrointestinal smooth muscle and enteric nervous system tissue
** Based on the treatment policy estimand: treatment effect regardless of if patients stayed on treatment or took other weight loss therapies
Current UK guidelines advise against their use in pregnancy and recommend concurrent effective contraception for women using them during their reproductive years
1 Due to the nature of invasive surgery coupled with the lack of a laboratory biomarker for the disease, both laparoscopy and laparotomy result in a delayed definitive diagnosis, thus leading to disease progression over time
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