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Similarly, TRT is not suitable for women and can have harmful effects if used during breastfeeding

For most GLP-1 trials, HR is included as a secondary safety endpoint, and the results have been inconsistent

Some individuals experience robust appetite suppression at 1.0 mg, while others require 2.4 mg or may reach a clinical plateau earlier

This suppression is mediated through multiple mechanisms: Paracrine Regulation (Somatostatin): GLP-1 receptors are highly expressed on pancreatic -cells