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The first head-to-head clinical trial (SURMOUNT-5, published in the New England Journal of Medicine in 2025) showed tirzepatide produced 20.2% average weight loss at 72 weeks compared to 13.7% for semaglutide approximately 47% greater relative weight loss
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Initially, you may experience mild side effects like nausea and diarrhea as your body adjusts, but these subside within a few days
When to Stop Tirzepatide Before Surgery: What You Need to Know If youre on tirzepatide (Mounjaro) for weight loss or managing type 2 diabetes, you may be wondering what to do if youre scheduled for surgery
