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It is about optimizing the relationship between efficacy and tolerability
Clinical trial data from the STEP program showed that people with prediabetes at baseline achieved normal A1c in 8485% of cases after 68 weeks of semaglutide
These changes occur in active sites, leading to a decrease in encoded protein activity, decreased excretion of foreign substances, and suboptimal catalytic efficiency
and (3) improvement rates from baseline of at least one fibrosis stage without any worsening of NASH (with worsening defined as an increase of 1 point in either the lobular inflammation score or the hepatocyte ballooning score according to the NASH CRN criteria) after 52 weeks of intervention
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