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Surgery success rates are generally good for pain relief (70 to 90% improvement in leg pain symptoms), but come with risks: infection, nerve damage, disc reherniation (5 to 15% recurrence rate after microdiscectomy), and adjacent segment disease with fusion (20 to 30% develop problems within 10 years)

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Similarly, mouse immature DCs were genetically engineered to secrete exosomes expressing the Lamp2 protein fused with the iRGD peptide (CRGDR/KGPDC) and demonstrated highly efficient targeted drug delivery to v integrin-positive breast cancer cells, consequently inhibiting tumor growth 36

Berven, H