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Most people start feeling reduced food interest during this phase
doi:10.1210/jc.2018-00448
Higher predisposition to adverse effects Additionally, people who had previously used gastrointestinal medications -- which may indicate they are more vulnerable to the common adverse gastrointestinal side-effects reported by GLP1-RA users, such as nausea, vomiting, diarrhea -- were 9% more likely to discontinue semaglutide within the first year
The STEP 1 trial, published in the New England Journal of Medicine in 2021, showed that participants taking semaglutide 2.4 mg weekly lost an average of 14.9% of their body weight over 68 weeks, compared to 2.4% in the placebo group
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