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They isolated the protein responsible, then synthesized the active 15-amino-acid fragment
The peptide's unique dual receptor mechanism, targeting both amylin (AMY1R, AMY2R, AMY3R) and calcitonin receptors (CTR), provides a novel approach to appetite regulation and metabolic control that goes beyond traditional GLP-1 therapies
Cell 185 , 24782494.e2428 (2022)
In addition, markers of liver fibrosis, including hyaluronic acid (HA), type III collagen (PC III), and laminin (LN), provide insights into the extent of extracellular matrix remodeling and fibrosis [12, 13]
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