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A contribution of NTS astrocytes to the appetite suppression caused by acute GLP-1R agonists also seems possible from evidence showing (1) expression of GLP-1Rs in this cell type, (2) functional responses of astrocytes to exendin-4 and liraglutide, and (3) negation of appetite suppression from administration of exendin-4 into the NTS when astrocyte metabolism is selectively inhibited in this region [56]

103105, 1993, doi: 10.1093/ajcn/58.1.103

Individual response varies significantly based on gut hormone sensitivity, metabolic rate, and GLP-1 receptor expression patterns