Recent data suggest that SAM coordinately regulates homocysteine remethylation and catabolism by inhibiting methionine-conserving enzymes with low K m values and activating methionine-catabolizing enzymes with higher K m values (Finkelstein, 1990
Store your medication toward the center of the cooler, away from the walls where temperature fluctuates most, and minimize how often you open the cooler
The tissue and cell disruption during processing (e.g., mixing, cutting, crushing, freezing/thawing, and high pressure treatment) makes native polyglutamyl folates accessible for endogenous conjugases (-glutamyl hydrolases) and results in the hydrolysis to monoglutamyl folates in vegetables (e.g., leeks, cauliflower, broccoli, spinach, soybeans, green beans, cowpea leaves, turnip, and carrot) and fruits (e.g., orange, papaya, sweet cherry, strawberry, and blackberry)
Either way, I agree it's good practice to monitor levels closely when someone starts these meds