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The company said that in its most recent clinical trial, the discontinuation rate due to side effects increased with the dosage, with the highest discontinuation rate, 11.3%, at the highest dosage of 12 mg
Attaching a fatty acid via a chemical linker to a specific residue on an already-assembled peptide requires controlling the proportion of conjugated versus unconjugated species, detecting and controlling free fatty acid or linker impurities, and monitoring for di- or poly-modification at unintended sites
Proactive Side Effect Planning: Develop a strategy for managing common transitions such as focusing on hydration and protein intake to address potential digestive changes before they occur
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