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[13] Inositol is generally well-tolerated, with mild gastrointestinal symptoms (nausea, flatulence, diarrhoea) being the most commonly reported side effects, usually at higher doses

If visible powder remains after 15 minutes total, the issue is likely insufficient diluent volume or a manufacturing defect in the lyophilization process

After removing it from the meta-analysis, the effect size for the MDS-UPDRS Part III (on medication) in endpoints shifted to non-significance, indicating that this study may have had a disproportionate influence on the overall findings (MD = 2.65

Important safety considerations include a boxed warning regarding thyroid C-cell tumors observed in rodents (though the relevance to humans is unknown) and contraindications for patients with a personal or family history of medullary thyroid carcinoma (MTC) or Multiple Endocrine Neoplasia syndrome type 2 (MEN2)