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Icaritin requires Phosphatidylinositol 3 kinase (PI3K)/Akt signaling to counteract skeletal muscle atrophy following mechanical unloading

25,26 Effects on Epicardial Adipose Tissue GLP1-RAs decrease the volume of epicardial adipose tissue, which is often elevated in HFpEF and is a source of proinflammatory cytokines and adipokines