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Various structural alterations were made at the N-terminal such as substitution of D-norleucine for L-norleucine, N-acetylation of norleucine, and replacement of norleucine with GABA in order to improve overall stability by reducing susceptibility to aminopeptidases
10.1016/j.bbrc.2010.05.003 43 HamptonS.CollinsF
Peptides are known in the scientific community as glycyl-L-histidyl-L-lysine (GHK), which can easily bind with copper enzymes
Early investigations indicated that incubating dermal fibroblasts with nanomolar concentrations of GHK-Cu may have increased the synthesis of collagen, elastin, glycosaminoglycans (GAGs), and small proteoglycans such as decorin
