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But if any of the following apply to you, your glutathione needs are likely elevated: Chronic digestive issues (IBS, IBD, SIBO, Candida overgrowth) Chronic fatigue or poor sleep Mood symptoms: anxiety, depression, brain fog Chronic infections or a history of immune dysfunction Significant toxin or alcohol exposure Heavy training or high athletic output Metabolic issues (obesity, blood sugar dysregulation) Neurological symptoms (tinnitus, cognitive decline) Older age

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doi: 10.1016/j.intimp.2025.114119 20 SuJZhengZBianCChangSBaoJYuHet al

The frequency depends on your health status, deficiency level, and health goals