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doi: 10.2147/ijn.s273713 Summary Keywords immunosuppression, immunotherapy resistance, nanomedicine delivery systems, osteosarcoma, translational oncology, tumor microenvironment (TME) Citation Huang Q, Yu G, Shi B and Deng T (2026) Engineering immunity in osteosarcoma: nanomedicine strategies for overcoming immune evasion

However, if their symptoms are typical of an anal fissure then it is still worth treating them, as per Primary Care Management, as well as making a referral