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Peptide-conjugated phosphodiamidate oligomer-mediated exon skipping has benefits for cardiac function in mdx and cmah-/-mdx mouse models of duchenne muscular dystrophy

Initial studies were conducted in animal models and progressed to human clinical observations, with particularly strong work on immune function, longevity markers, and circadian regulation

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If one were to extrapolate from existing human trials: Dose: 0.51 mg per day Route: Sublingual or subcutaneous Duration: Up to 20 days (as used in circadian gene studies) Yet these regimens should not be considered prescriptive or approved protocols