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In severe cases of dehydration, the body conserves water by reducing urine production, leading to infrequent or dark-colored urine

However, TAD2 shows only a mild preference for an -helical conformation, which appears to be slightly stabilized in presence of FOXO4 FH (Supplementary Fig

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The combined activation of these three pathways is being investigated for additive or synergistic effects across metabolic research