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Open Neurol
Through systematic fractionation of human albumin, Pickart and colleagues isolated a small peptide responsible for the difference, eventually identifying it as a three-amino-acid sequence glycine, histidine, and lysine with an unusually strong affinity for binding copper(II) ions
Together, these findings support the hypothesis that VPA induces oxidative stress in specific brain regions, such as the hippocampus, while LipRSV may exert region-specific antioxidant effects, though not uniformly across the brain
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