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Notably, a study in A plaque-bearing Tg2576 mice, initiated at 14 months of age, showed no significant impact on relieving oxidative damage, even with elevated plasma melatonin levels [165]
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Iron accumulation and lipid peroxidation in -cells, driven by mitochondrial dysfunction and inflammatory cytokines like IL-1 and IFN- produced by T cells and macrophages, lead to -cell dysfunction and apoptosis (105, 106, 109, 146)
Through the inhibition of phosphoinositide 3-kinase (PI3K), 3-MA disrupts the formation of autophagosomes, thereby impeding the initiation of the autophagic process
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