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Some cases are recorded, but there are a few things to consider

[95] Intramuscular or intravenous injection [edit] Injection of hydroxycobalamin is often used if digestive absorption is impaired, [2] but this course of action may not be necessary with high-dose oral supplements (such as 0.51.0 mg or more), [97] [98] because with large quantities of the vitamin taken orally, even the 1% to 5% of free crystalline B 12 that is absorbed along the entire intestine by passive diffusion may be sufficient to provide a necessary amount

The 2000 mcg twice weekly IM protocol is effective in studies

The recommended daily intake for adults is 2.4 micrograms, but higher doses are also considered safe, as your body absorbs only what it needs, and any excess is passed through urine