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L-ornithine L-aspartate (LOLA) Ammonia detoxification is achieved by two main pathways in periportal hepatocytes: 1) urea synthesis in zone 1 and 2) glutamine synthesis in zone 3

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The mechanism of action was later discovered to be chemically-mediated mitochondrial uncoupling put very simply, chemicals knock holes in the mitochondrial membrane and force the mitochondria to work really hard to reverse the dissipation of membrane potential, which generates heat and reduces weight