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The STEP 1 clinical trial demonstrated average weight loss of approximately 15% of body weight over 68 weeks with semaglutide 2.4mg, but these results were achieved in conjunction with dietary counselling and a 500 kcal per day calorie deficit, as highlighted in NICE TA875
Among participants with a starting BMI of at least 35 who continued into an extension period, average weight loss reached 30.3% at 104 weeks
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