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1 While Nooms compounded drugs are produced in an FDA-regulated pharmacy, the drugs themselves are not FDA-approved and do not undergo FDA safety, efficacy, or quality review.

Figure 7: Changes in the levels of A) IL-1-beta, B) TNF-alpha, and C) IL-10 in each of the four different experimental groups included in the first part of the study

Likewise FDA-approved agents like Topotecan, a topoisomerase I inhibitor, were found to carry inhibitory effects on HIF-1 translation (156, 158, 160)

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