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Despite its utility, NO abuse has increased because of its ability to induce brief euphoria when inhaled

In the NETTER-I phase III clinical trial, it was demonstrated that 4 cycles of PRRT with [ 177 Lu]Lu-[DOTA,Tyr 3 ]-octreotide ([ 177 Lu]Lu-DOTA-TATE) in combination with octreotide LAR resulted in longer progression-free survival and higher response rates in patients with advanced midgut NETs, compared to high-dose octreotide LAR treatment alone [29]

1.7 Epigenetics The study of heritable adjustments in gene expression patterns which do not result from changes the DNA sequence is identified as epigenetic changes