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No major safety signals emerged in Phase 2, which is genuinely encouraging
Small-molecule drugs such as orforglipron offer better oral bioavailability, but their receptor interaction profile may differ subtly from that of peptide GLP-1 agonists, which could account for some of the efficacy differential
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They are not FDA-approved finished drug products, meaning they are not subject to the same quality, potency, and sterility standards as the branded versions
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