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Notably, senkyunolides, core bioactive compounds derived from traditional anti-migraine herbs like Ligusticum chuanxiong , have emerged as promising candidates due to the role of multidimensional homeostasis in regulating neurovascular units (suppressing activation of the trigeminal vascular system, modulating pathological vascular alterations, modulating neurotransmitters and receptors, inhibiting inflammatory response, antioxidant stress and analgesic effects and improving blood-brain barrier integrity) and unique pharmacokinetic advantages (small-molecule structure enabling blood-brain barrier penetration, natural origin reducing hepatorenal toxicity risks)
These results could support a model in which TJ opening is a continuous process linearly tuned by luminal signal intensity (putrescine concentration) subsequently resulting in increased permeability
Improved self-confidence and motivation to continue
Throughout this journey, motility changes occur, along with chromatin changes
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