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Preclinical and in vitro data examined across GHS-R1a and GHRH-R literature suggest that concurrent receptor stimulation may produce somatotroph GH secretory responses that research indicates might exceed those attributable to single-receptor stimulation alone

The albumin-binding CJC-1295 (DAC) healthy-adult study used weight-based subcutaneous dosing, with roughly 30 to 60 mcg/kg reported as the doses that were safe and relatively well tolerated in ascending single and multiple-dose trials of the DAC form a completely different pharmacokinetic entity from no-DAC

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