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A: Yes, B12 injections have an excellent safety profile
found that fast escalation to 8 mg produced GI adverse events in 50% of participants, compared to roughly 35% with gradual titration (Rosenstock et al., Lancet, 2023)
By influencing S-adenosylmethionine (SAM) levels, it also plays a role in epigenetic regulation and longevity-related gene expression, linking energy metabolism with cellular lifespan
This means you would either need a larger syringe or split your dose into two injections
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