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It is now known that GLP-1 receptors are widely expressed in the hypothalamus, hindbrain and amygdala with a neuronal link between the periphery and CNS to regulate GLP-1 action (42)
However, a separate Phase 3 study in paediatric patients showed clinically meaningful overall survival, prompting AstraZeneca to proceed with regulatory submissions for the paediatric indication while continuing discussions with health authorities regarding the adult program
Aging Cell 16(4):815-817
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