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When B12 levels become problematic: High-dose supplementation (particularly doses exceeding 1,000 micrograms daily) Frequent B12 injections without medical supervision Underlying conditions affecting B12 metabolism Concurrent use of multiple B12-containing supplements The NHS does not set an upper safe limit for vitamin B12 because harmful effects from excessive intake have not been definitively established
Anecdotal evidence from user communities provides additional perspective
R.CozzolinoF.RotilioG.et al (2003)
More concerning than the weak evidence is the regulatory position
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