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DOI: 10.1371/journal.pone.0125879
By weeks 5 through 8, more substantial structural changes emerge tissue resilience improves, stiffness decreases, and strength recovery accelerates
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Wegovys clinical studies overview lists, among its trials, one 68-week, randomized, double-blind, placebo withdrawal trial. Zepbound describes its Study 4 as an 88-week randomized withdrawal trial in which all patients received open-label ZEPBOUND during a 36-week lead-in period, followed by randomization to either continue ZEPBOUND or switch to placebo for 52 weeks. These are the FDA-reviewed accounts of what happens to people who come off, printed in the label, available to any prescriber
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