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A study showed that induction of SCI in mice by applying vascular clips to the dura following a four-level laminectomy at the T5T8 vertebrae caused severe damage, including edema, tissue injury, increased apoptosis, and inflammation (Genovese et al
PLE is a hydrophilic extract from the tropical fern Polypodium leucotomos , rich in phenolic antioxidant compounds and with a strong safety profile [129,130,131,132,133]
Be Aware of Digestive Effects: Berberine can cause gastrointestinal discomfort in some individuals
Concentrations are stronger, and professional oversight becomes essential to ensure safety and efficacy
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