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The timing and dosing of liraglutide were selected based on prior rodent self-administration studies, e.g., heroin and alcohol models (Marty et al., 2020

There is no conclusive evidence that semaglutide induced cancer development in tissue, which may imply that the development of cancer may pertain to other causes rather than semaglutide application [129]

Mitophagy constitutes a critical adaptive survival mechanism for tumor cells under therapeutic pressure by eliminating treatment-induced damaged mitochondria, limiting reactive oxygen species accumulation, and maintaining mitochondrial homeostasis, thereby providing a buffering capacity for the development of resistance

This is a substantial number and one that often gets overlooked in discussions focused on GI side effects