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Osmotic stress as well as flooding stress alters cytosolic pH, activating GAD and subsequently elevating GABA production under acidic conditions (Komatsu et al

Biol Psychiatry 92:450459

Drink water consistently throughout the day

In TRIUMPH-4, dysesthesia (abnormal sensations: tingling, prickling, burning, numbness) was reported by 8,8% of participants in the 9 mg dose range and 20,9% of participants in the 12 mg dose range