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(31) showed that neurons in the brains of patients with T2DM secrete the regulatory factor angiopoietin-like protein 8 (ANGPTL8) into the hippocampus, which activates microglia to up-regulate pro-inflammatory factors and axonal damage, leading to cognitive impairment
Doerr, H.W
Indeed, in pre-clinical models, retatrutide, a triple agonist (GLP-1/GIP/glucagon), resulted in greater WL and improved glucose profile compared to tirzepatide through increased energy expenditure and reduced calorie intake [80, 81]
The research community continues to watch P140 development closely, as it represents a proof of concept for peptide-based tolerogenic approaches to lupus
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