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This toll on our states health is also a toll on our economy, costing an estimated $10.7 billion a year, or nearly 2% of GDP

184,185,186,187 Interactions with other pathways GLP-1 not only promotes the release of insulin but also enhances the response of pancreatic -cells to insulin through the PI3K/Akt pathway, thereby improving insulin signal transduction and increasing the sensitivity of peripheral tissues to insulin