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Molecular Aspects of Medicine, 30(1-2), 1-12
To date, there are more than 530 genes that have been shown to be directly regulated (either positive or negative) via interaction with retinoic acid bound RAR or RXR
In individuals with primary coenzyme Q 10 deficiency, early treatment with high-dose coenzyme Q 10 supplementation (1030 mg/kg/day in children and 1.23.0 g/day in adults) may improve the pathological phenotype, yet the effectiveness depends on the type of mutations affecting the coenzyme Q 10 biosynthetic pathway (1, 26)
There are also broader metabolic considerations such as metabolic syndrome, vascular aging and need to monitor protein intake to support muscle building and recovery
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