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SURMOUNT-5: the definitive comparison SURMOUNT-5 is the first large-scale, randomized, controlled trial directly comparing tirzepatide and semaglutide for obesity treatment
40 (14), e100715
Higher mean age and baseline SBP, greater use of anti-hypertensive medications, longer T2D duration, and reduction in insulin daily dose might have contributed to explain the difference observed in the impact of weight loss on SBP reduction in these trials, although direct GLP-1R- and GIP-R-mediated effects could also be considered [77]
PMCID: PMC10732203
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