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In the only trial that directly compared the two so far (REDEFINE 4), Mounjaro produced slightly more weight loss than CagriSema (25.5% vs 23.0% over 84 weeks), and CagriSema didnt meet the trials main goal
A higher blood level is not the same as a health benefit A trial can demonstrate absorption or a biomarker increase without proving that participants feel better, function better, avoid disease, or live longer
Monomeric alpha-synuclein induces blood-brain barrier dysfunction through activated brain pericytes releasing inflammatory mediators in vitro
Thats important for increasing B12 levels in people who cant properly absorb B12 from food or supplements
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