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Current research on the role of the gutbone axis in osteoporosis mainly targets the regulation of bone metabolism by intestinal factors, the pathogenesis and therapeutics of osteoporosis, and the interaction of the gutbone axis with other systems
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It plays a role through a specific GLP-1 receptor (GLP-1R) distributed in many organs or tissues and participates in the regulation of glucose homeostasis in the body
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Despite its broad therapeutic potential, PPRs clinical applications are limited by its dose-dependent toxicity and potential interactions with pharmaceuticals
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