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Rangaswamy R, Singh CG, Singh HM, Punyabati P, Nyuwi KT

The xenobiotic adaptation in arthropods evolves through multiple mechanisms (Figure 1) [13, 14], including reduced penetration through the cuticle, behavioral avoidance [15, 16], microbiome-mediated detoxification [17-20], enhanced metabolic detoxification [21-25], enhanced sequestration or excretion [13, 19, 26, 27], and target site insensitivity [28-32]

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Traditional oral glutathione is poorly absorbed (only ~10% reaches the bloodstream), while IV therapy is costly and temporary