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Retatrutide (a triple GIP/GLP-1/glucagon receptor agonist), survodutide, mazdutide, and CagriSema represent the next generation of anti-obesity compounds that may offer even greater efficacy or better tolerability profiles

In a phase 2 trial, once-weekly cagrilintide produced dose-dependent weight reductions in people with overweight or obesity, which is what moved the amylin pathway into serious combination development ( Lau et al., Lancet 2021 )

The combination matters because GHK-Cu (glycyl-L-histidyl-L-lysine copper) cannot permeate intact human skin

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