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The selection of Medical Subject Headings (MeSH) and Emtree (Embase Subject Headings) was made in order to conduct searches on the online databases: (Bupropion OR " naltrexone " OR " Amfebutamone " OR " Wellbutrin " OR Zyban " OR Quomen OR Zyntabac ) AND (weight OR Waist Circumference OR Body Mass Index) AND (Clinical Trials as Topic OR Cross-Over Studies OR Double-Blind Method OR Single-Blind Method OR Random Allocation OR Clinical Trial)

Axxams metabolic platform assays Enteroendocrine cells act as nutrient sensors in the gut, detecting dietary components through receptors located on their luminal surface