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Exenatide had 53% homology with GLP-1, had strong binding ability with GLP-1 receptor and was not easily degraded by DPP-4
Cytochrome P450 oxidoreductase contributes to phospholipid peroxidation in ferroptosis
Expert consensus suggests considering pharmacotherapy when there is: Significant weight regain from nadir weight BMI 27 kg/m with obesity-related comorbidities or BMI 30 kg/m Absence of anatomical complications requiring surgical revision Adequate adherence to nutritional and behavioral recommendations Patient willingness to engage in long-term pharmacotherapy The American Association of Clinical Endocrinologists (AACE) and American College of Endocrinology (ACE) guidelines emphasize that pharmacologic therapy should complement, not replace, lifestyle interventions and ongoing bariatric surgical follow-up
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