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The satiety produced by amylin analogues tends to reduce caloric intake without the extreme food aversion that sometimes occurs with high-dose GLP-1 agonists, which can lead to inadequate protein intake and subsequent muscle loss
Oral and sublingual routes require dose escalation to compensate for poor bioavailability, but higher doses do not proportionally increase absorptionthey increase the fraction of peptide degraded in the GI tract and the intensity of the bitter taste
Statistical significance was determined using an unpaired two-tailed t-test with Welchs correction and an ordinary two-way ANOVA with Tukeys multiple comparison test
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